BRAF and adenocarcinoma: - ECOG 0 or 1- ≥ 18 and <70 years- BRAF wild-type- High standard oncological surgical resection of the primary*- Histologically proved adenocarcinoma in the colon or rectum- Time from primary surgery to WL ≥6 months- At least 2 months of stable disease or partial response according to RECIST 1.1- At least 1 CT line treatment (3 months)- CEA stability or reduction- No extrahepatic disease, expect for lung metastases (up to three resectable nodules or liable to radiotherapy with no progression after 3 months)- Resected hilar hepatic adenopathy with no progression after 3 months