BRAF and metastatic neoplasm: - ECOG 0 or 1- ≥ 18 and ≤ 65 years- Histologically proved adenocarcinoma in colon or rectum- BRAF wild-type- High-standard oncological surgical resection of the primary*- No local recurrence on colonoscopy- ≥ 3 months of tumor control during the last CT line: stable or partial response on RECIST criteria- ≤ 2 lines of CT for metastatic disease- CEA <80 microg/L or a decrease ≥ 50%- No extrahepatic tumor