- ECOG 0- Histologically confirmed non-mucinous colon adenocarcinoma- pT1-3, pN0 or pN1 (metastases in <4 regional lymph nodes), confirmed R0 resection.- RAS and BRAF wild-type- Objective response according to RECIST 1.1 to first-line treatment, with sustained response for at least 4 months, OR disease control (CR + PR + SD) during the second-line treatment for at least 4 months.- A maximum of two prior CT treatment lines.- CEA <50 ng/ml. Here, BRAF is linked to colon mucinous adenocarcinoma.