- ECOG 0 or 1- ≥ 18 years- Histologically proved adenocarcinoma in the colon or rectum- Primary tumor removed with an R0 resection- No extrahepatic or local recurrence- At least 2 months of CT with no signs of progression- >1 year from initial diagnosis- BRAF wild-type. The gene discussed is BRAF; the disease is adenocarcinoma.