- ECOG 0 or 1- ≥ 18 and <70 years- High-standard oncological surgical resection of the primary*- BRAF wild-type- At least 1 CT line treatment (3 months)- No extrahepatic or local recurrence- No hepatic lesions > 10 cm before CT treatment- Tumor response according to RECIST 1.1 on two stadiation with no CEA elevation- If tumor response after CT <10%, only in 20% tumor reduction after TACE (DEB-IRI) o 90Y-spheres- Time from primary surgery to WL ≥10 months- CEA <100 ng/ml. The gene discussed is BRAF; the disease is neoplasm.