Our study also showed that ITGA5, ITGB2, and ITGB5 may mediate the migration of leukocytes from blood vessels to skin tissue by interacting with chemokines (CXCL12, CCL2) and vascular endothelial cell adhesion molecules (JAM3/CDH5/ICAM 1/PECM1) and participate in the immune inflammatory process of SSc. The gene discussed is JAM3; the disease is systemic sclerosis.