Inhibition of Wee1 by adavosertib was recently described as a highly effective single-agent treatment for HPV-positive HNSCC dependent on FOXM1 activation (55) and single agent radio- and chemosensitization through PARP, as well as through intra-S/G2 checkpoint inhibition, which was repeatedly demonstrated in HPV-positive HNSCC models (10, 21–23, 25, 30, 31, 56, 57). This evidence concerns the gene WEE1 and head and neck squamous cell carcinoma.