For example, the uptake of these factors by SCARF1 could prevent neutrophil and macrophage accumulation in the tumor microenvironment, thus providing an alternative mode-of-action for the anti-tumoral action of SCARF1, as myeloid cell accumulation is often associated with poor prognosis in HCC (63, 64). The gene discussed is SCARF1; the disease is hepatocellular carcinoma.