Here, through the utilization of the publically-available TGCA (The Cancer Genome Atlas) RNA-sequencing datasets (http://cancergenome.nih.gov), we describe the differential regulation of scavenger receptors in HCC tumor tissues, compared to non-tumorous control tissues, and specifically focussed on the downregulation of SCARF1 expression. The gene discussed is SCARF1; the disease is hepatocellular carcinoma.