The STRING enrichment analysis of the core of 23 TFs common to all vtRNAs identified HTLV-I infection (ATF1, ATF3, E2F1, EP300, NFATC3, TBP), Hepatitis B (E2F1, EP300, NFATC3) and Transcriptional misregulation in cancer (AFF1, ATF1, MAX) as the top three enriched KEGG pathway terms (FDR < 0.05) (Figure 3D andExtended Data: Table S6). The gene discussed is E2F1; the disease is cancer.