As a signal pathway initiated by the binding of tyrosine kinase receptor family and its ligand SCF, c-kit not only plays an important role in the regulation of hematopoietic stem cells and melanocytes but also plays an important role in the differentiation and development of ICC, phenotypic maintenance, and the stability of gastrointestinal rhythmic activity [36]. Here, KIT is linked to intrahepatic cholangiocarcinoma.