Previous studies had demonstrated that the overexpression of NUSAP1 was observed in many human neoplasms including colon cancer (Han et al., 2018; Liu et al., 2018), astrocytoma (Wu et al., 2017), glioblastoma multiforme (Qian et al., 2018), renal cell carcinoma (Fang et al., 2016), prostate cancer (Gulzar et al., 2013; Gordon et al., 2015, 2017), oral squamous cell carcinoma (Okamoto et al., 2015), breast cancer (Kretschmer et al., 2011; Chen et al., 2015), cervical carcinoma (Li et al., 2019), and esophageal squamous cell carcinoma (Guan et al., 2019). The gene discussed is NUSAP1; the disease is esophageal squamous cell carcinoma.