BSCL2 and Charcot-Marie-Tooth disease: These variants, all in heterozygous status, all fall in one of those genes associated with autosomal dominant and recessive CMT: AGRN, SCP2, DNM2, MED25, DYNC1H1, and BSCL2. This high number of VoUS is in line with the previous studies reporting a higher number of VoUS in neuropathy-associated genes, including single mutations in autosomal recessive CMT genes compared with the control population, with some patients presenting more than one VoUS in different CMT genes (Gonzaga-Jauregui et al., 2015).