KIF5A and hereditary spastic paraplegia: For example, mutations in the N-terminal motor domain of KIF5A are responsible for hereditary spastic paraplegia (SPG10 MIM 604187) and CMT type 2 (CMT2), clustered in the switch regions SWI (199–204) and SWII (232–237) necessary for microtubules interaction (Filosto et al., 2018).