Then, two independent studies reported different HSPB1 mutations in two sporadic cases and one consanguineous family with ALS, suggesting that the disease spectrum of HSP27 may not be limited to CMT2/dHMN (Scarlato et al., 2015; Capponi et al., 2016; Adriaenssens et al., 2017). Here, HSPB1 is linked to amyotrophic lateral sclerosis.