CD8A and neoplasm: At first glance, both tumor- and chronic virus-specific CD8+ T cells possess significant enrichment of genes related to recent TCR signaling (Batf, Egr2, Ezh2, Irf4, Nfatc1, Nfatc2, Nr4a1, Nr4a2, and Nr4a3) (17, 18, 23–25).