In the absence of ICB and irrespective of primary tumor PD-L1 expression, enhanced PD-1/PD-L1 contacts between stem-like PD-1loCD8+ Tex and migratory PD-L1+ DCs entering the paracortex of tumor-draining LNs negatively correlates with survival of mice exposed to AC29 tumors and non-metastatic melanoma patients following resection (89). Here, PDCD1 is linked to metastatic melanoma.