To identify the potential purinergic receptors that were dysregulated in colitis, we first analyzed two Gene Expression Omnibus (GEO) datasets (GSE59071 and GSE53306) containing expression profile of actively inflamed mucosa from colitis patients, and one GEO dataset (GSE22307) containing expression profile of colon tissues from DSS-induced mouse colitis. This evidence concerns the gene P2RX7 and colitis.