ERO1L expression showed strong correlations with markers for infiltrating lymphocytes including regulatory T cells (Tregs), exhausted T cells, macrophages, tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and cancer-associated fibroblasts (CAFs), thus indicating infiltrations of immune-suppressive cells are mediated by ERO1L signaling (Figure 4A). This evidence concerns the gene ERO1A and neoplasm.