We found that compared to tumors with low HSPA7 expression, tumors with high HSPA7 expression exhibited significantly increased myeloid cell-derived macrophage-restricted chemokines (8, 25) (Supplementary Figures S4D, E); we also confirmed that HSPA7 could facilitate the macrophage infiltration into the GBM TME via YAP1–LOX axis in vitro, as well as into our local GBM tissue sections (Figures 7A–G). This evidence concerns the gene YAP1 and glioblastoma.