Further GSVA enrichment analysis showed that compared to the HSPA7-low group, the HSPA7-high group exhibited higher TME immune cell infiltration with higher immune and stromal scores, lower tumor purity (Supplementary Figure S11A), higher stromal activation, higher oncogenic pathway activation, and lower MMR pathway activation (Supplementary Figure S11B), completely consistent with the functional enrichment patterns in GBM (Figures 3A, 4A and Supplementary Figures S5C, S6C). This evidence concerns the gene MRC1 and glioblastoma.