(52) found that PTEN deficiency in GBM increases the infiltration of SPP1+ macrophages, which can interact with fibroblasts and vascular endothelial cells, inducing angiogenesis, EMT, and some other stromal activation-related pathways in colon cancer and are characterized by expression of the pattern recognition receptor MARCO (59) via a YAP1–LOX-β1 integrin–PYK2 axis. Here, SPP1 is linked to malignant colon neoplasm.