PTEN and glioblastoma: We then analyzed the differences in the distribution of somatic mutations between the low and high HSPA7 expression groups in the TCGA GBM cohort using the “maftools” package and found that the PTEN mutation rate was significantly increased in the HSPA7-high group compared to the HSPA7-low group (Figure 6K; low: 20%, high: 36%).