HSPA7 and neoplasm: To identify specific macrophage cell populations linked to HSPA7 expression in GBM, we examined the TCGA GBM dataset for TAM MG and TAM BMDM using validated gene set signatures (25), which demonstrated that tumors with high HSPA7 expression exhibited significantly increased infiltration of TAM BMDMs, while TAM MG was significantly decreased (Figure 3A and Supplementary Figure S3A), suggesting that HSPA7 enhanced recruitment of tumor-promoting BMDMs into the GBM TME rather than MG.