SPP1 and glioblastoma: Moreover, LOX and YAP1 expression levels were enhanced upon overexpression of HSPA7 in PN subtype GSCs 8–11 (Figures 7C, D) but decreased significantly upon knockdown of HSPA7 in MES subtype GSCs 267 (Figure 7D), suggesting that HSPA7 may facilitate tumor promoting macrophage infiltration by enhancing LOX expression, which could promote macrophage migration into the GBM TME and enhance angiogenesis by upregulating TAM-derived SPP1 (52).