CCNE1 and neoplasm: Moreover, previous studies indicated that F-box and WD repeat domain containing 7 (FBXW7) is a vital tumor suppressor in various cancers, controlling proteasome-mediated degradation of oncoproteins such as cyclin E, c-Myc, Mcl-1, mTOR, Jun, and Notch (48) and that its loss-of-function mutation promotes resistance to anti-PD-1 therapy through downregulation of vital sensing pathways (49).