In addition to NKG2D, we focused on its ligand, the MHC class I poly-peptide-related sequence A (MICA), as well as markers indicating increased donor graft immunogenicity (HLA-DRB), immune activation (CCL19), obesity (Leptin) and alternative Natural Killer (NK) cell receptors (DNAM-1). The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.