MAPK3 and cancer: Concerning adiponectin, which circulating levels is inversely correlated to obesity, in vitro studies have shown its inhibitor role in proliferation and apoptosis in cancer cell line such as liver, breast, endometrium and stomach through the activation of AMPK and the inhibition of PI3K/Akt, ERK1/2 pathway, NF-κB, Wnt-β-catenin pathway (70).