For example, it would be interesting to examine if alterations to BDK (and related enzymes involved in BCAA catabolism) in insulin resistant/diabetic individuals are sex-dependent, and if such differences are somewhat linked to differences between the sexes in measures of protein metabolism and abnormalities associated with insulin resistance and its sequelae like T2DM and cardiovascular disease. The gene discussed is BCKDK; the disease is cardiovascular disorder.