A number of studies have reported that SIRT1, one of the members of class III histone deacetylases enzymes, inhibits apoptosis in cardiomyocytes (Tanno et al., 2010; Yu et al., 2016) and its reduction is associated with various cardiovascular pathologies such as cardiac hypertrophy and the severity of heart failure (Kong et al., 2010; Sosnowska et al., 2017). The gene discussed is SIRT1; the disease is heart failure.