Raychaudhuri et al. demonstrated that FR255734, a humanized, Fc-silent, anti-CD28 antibody, effectively inhibited T cell activation by blocking CD28/B7 co-stimulatory interactions and improved the thickness of epidermis and reduction in lymphocytic infiltration in a mouse psoriasis model (Raychaudhuri et al., 2008). The gene discussed is CD28; the disease is psoriasis.