FGF2 and early-onset autosomal dominant Alzheimer disease: In summary, the results from the aforementioned studies emphasize the important role of the bFGF in neural differentiation and promise new therapeutic strategies by using the bFGF to treat neurological diseases and repair neuronal damage, such as spinal cord injury (SCI), Parkinson’s disease, neonatal hypoxia-ischemia (NHI), and Alzheimer’s disease (Barzilay et al., 2008; Zhang et al., 2014; Luo et al., 2018a; Ye et al., 2018).