In the LUAD-to-LUSC transdifferentiation model driven by Sox2 overexpression alongside co-deletion of Stk11 and Nkx2-1, it was found that, in contrast to peripheral blood neutrophils, tumour-associated neutrophils (TANs) produce increased levels of ROS and include a subpopulation of cells expressing high levels of sialic acid-binding immunoglobulin-like lectin F (SiglecF)67. This evidence concerns the gene SOX2 and neoplasm.