The associated increase in DNA damage triggered by WEE1 inhibition and consequent CDK1 activation stimulated expression of type 1 interferon (IFN) signalling and major histocompatibility complex (MHC) class I antigen presentation genes in LUSC cells, increased tumour-infiltrating CD8+ T cells, and decreased TANs35. The gene discussed is WEE1; the disease is neoplasm.