Similarly, a prospective study carried out in 63 patients with CKD showed that patients with serum soluble Klotho levels in the lower quartile (< 309 pg/mL) had significantly higher cardiovascular and all-cause mortality rates (hazard ratio = 4.17, 95% CI = 1.29–13.48, P = 0.018)35. Here, KL is linked to chronic kidney disease.