KL and chronic kidney disease: CKD patients with higher Klotho (tertiles 3), presented significantly higher ABI values (P < 0.001 for both Klotho determinations) and reduced CIMT (P < 0.001 for serum levels and P < 0.01 for KL expression in PBCs), which resulted in a lower prevalence of subclinical atherosclerosis (P < 0.001 for both determinations of Klotho).