Therefore, in the current study, we examined the interaction of CETP TaqB1 with dietary insulin index and load, in altering on cardiovascular risk factors including obesity indices (WC and BMI), lipid profiles (TG, HDL, LDL/HDL), inflammatory markers (IL-18, CRP, and PGF2α), and antioxidant markers (TAC and SOD). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.