The key findings of the current study were the significant interaction result of CETP rs708272 polymorphism with DIL and DII on obesity indices (WC and BMI), lipid profiles (TG, HDL, LDL/HDL), inflammatory markers (IL-18, CRP, and PGF2α), and antioxidant markers (TAC and SOD) in T2DM patients. This evidence concerns the gene CETP and obesity due to melanocortin 4 receptor deficiency.