Our data also shows reduced sialylation on both IGG1 N299 and IGHG2 N176 by 2.1% (corresponding to a relative change of 21.3% and 26.8% respectively), which is also in agreement with literature as reduced sialylation has been described as a major alteration in PCa compared to healthy individuals55. Here, IGHG2 is linked to posterior cortical atrophy.