Curative i.t. treatment with artLCMV-TRP2 was dependent on self-antigen expression by the tumor cells and self-antigen-delivery by the vector, as demonstrated by the failure to eliminate TRP2-deficient tumor cells (B16F10-Dct−/−, Fig. 1d and Supplementary Fig. 1b) and the lack of long-term tumor control when artLCMV vectors expressing irrelevant antigens were applied (artLCMV-green fluorescent protein (GFP), Fig. 1e). Here, DCT is linked to neoplasm.