Moreover, the production of effector cytokines in adoptively transferred P14 T cells (T cell receptor transgenic CD8+ T cells specific for the LCMV epitope GP33-41) was significantly decreased by Il33-ablation in Cxcl13-Cre+ tumor FSCs and deficiency of the IL-33 receptor ST2 on transferred P14 T cells (Supplementary Fig. 8a–c). The gene discussed is IL33; the disease is neoplasm.