The verified results of western blotting showed that APG-1252-M1 plus gemcitabine markedly reduced the levels of phosphorylated STAT3 (Y705) in all three NPC cells, while it did not change the levels of p-FYN+p-YES in NPC cells (Fig. 5e, f; Supplementary Fig. 5b). Here, STAT3 is linked to nasopharyngeal carcinoma.