We would like to highlight that atomization inhalation of 10 mg plasminogen dissolved in 2-ml sterile water given twice daily in five clinically moderate patients with COVID-19 has been shown to improve the conditions of lung lesions, heart rate, and oxygen saturation, about 1 h after the first inhalation, suggesting that plasminogen may be effective and efficient in treating several complications during COVID-19 infections. Here, PLG is linked to COVID-19.