Along those lines, a comparison of the afucosylated versus parental L1CAM-targeting IgG1 in tumor-naïve athymic nude mice revealed a lower radioactivity concentration of 89Zr-HuE71-IgG1-Afuco in the blood at 120 h after injection, suggesting faster in vivo pharmacokinetics (Supplemental Fig. 5), which is consistent with our findings for this variant in SKOV3-xenografted mice. The gene discussed is L1CAM; the disease is neoplasm.