MAPT and supranuclear palsy, progressive, 1: Autosomal dominant mutations in the tau gene (MAPT) cause frontotemporal lobar degeneration and common risk alleles, notably the MAPT 17q21.31 H1 haplotype, are associated with sporadic tauopathies including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and argyrophilic grain disease (AGD) [10].