Moreover, we sought for associations between PVS with additional CSF biomarkers of several pathophysiological mechanisms involved in AD and other neurodegenerative disorders such as axonal damage (NfL), synaptic dysfunction (neurogranin), microglial (sTREM2), astroglial-related response (GFAP, YKL40, S100), other neuroinflammatory biomarkers (IL6), and α-synuclein. The gene discussed is NRGN; the disease is Alzheimer disease.