Furthermore, we stratified the analyses in Aβ + and Aβ- individuals to study the associations between ePVS and CSF biomarkers within and outside the Alzheimer’s continuum. Therefore, the fact that p-tau, t-tau, and neurogranin survived the correction for CSF Aβ40 levels in Aβ + individuals supports the association of ePVS with core AD pathophysiological mechanisms. This evidence concerns the gene NRGN and Alzheimer disease.