AKT1 and neoplasm: Functionally, re-introduction of Q387R or Q387H-PDK1 into DLD1-PDK1−/− cells could significantly enhance AKT-pT308 (Fig. 6F), cellular colony formation and soft agar growth in cells (Fig. 6G-H, S5E), and tumor growth in vivo (Fig. 6I-K, S5F-G).