Interestingly, hypocretin receptor-expressing preneutrophils reside near HSPCs, but sleep-induced hypocretin stimulation from the hypothalamus keeps restricting M-CSF (mature neutrophils have higher M-CSF expression),157 highlighting preneutrophils as niche cells for regulating myelopoiesis related to the severity of atherosclerosis. Here, HCRT is linked to atherosclerosis.