In chronic inflammation with obesity, the S100A8/S100A9-IL-1β axis in adipose tissue promotes myelopoiesis.155 In hyperglycemia, neutrophil production and increased plasma levels of S100A8/S100A9 enhance myelopoiesis from MyP cells,60 indicating that stimulated neutrophils promote myelopoiesis in the BM. The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.