TNF-α in chronic stimulation promotes HSC survival and myeloid differentiation by activating a strong and specific p65-NF-κB-dependent gene program that primarily prevents necroptosis, and poises HSCs for myelopoiesis.48 TNF-α production from HSPCs is increased in hypercholesterolemia.75 The gene discussed is TNF; the disease is Hypercholesterolemia.