In addition, we note specific upregulation of alarmins S100A8/S100A9 (i.e., calprotectin) among epithelial cells in the severe COVID-19 group compared to mild or moderate and control counterparts, and even higher expression of S100A9 within SARS-CoV-2 RNA+ cells from those same individuals. The gene discussed is S100A9; the disease is COVID-19.