Loss of varying numbers of these motifs by APC truncating mutations within the intestinal stem cell compartment confers high basal β-catenin levels and initiates up to 80% of colorectal cancers (CRCs) (Barker and Clevers, 2006; Kohler et al., 2008, 2009; Morin et al., 1997; Munemitsu et al., 1995; Novellasdemunt et al., 2017; Roberts et al., 2011; Rubinfeld et al., 1997; Zhang and Shay, 2017), the third most common cancer type worldwide (Bray et al., 2018). Here, APC is linked to cancer.