APC and colorectal carcinoma: We individually expressed full-length APC, the aforementioned CRC truncation variants, and an APC variant lacking the so-called β-catenin-inhibitory domain (CID), which is essential for the suppression of β-catenin levels in cells (Choi et al., 2013; Kohler et al., 2009; Liu et al., 2006; Novellasdemunt et al., 2017; Roberts et al., 2011).