While preferential IGHV gene usage was reported in early studies of RBD‐specific Abs, the response to the full trimeric S protein is quite diverse and engages many different IGHV genes, including those that are also highly used in many other viral infections and in the IgG repertoire in general, such as IGHV1‐69, IGHV3‐23, IGHV3‐30 and IGHV3‐30‐3 [88, 103, 104, 105]. The gene discussed is DDX41; the disease is viral infectious disease.