GK and Cowden syndrome 1: While the precise viral pathogenicity determinant in ocular disease remains to be elucidated, we have shown that mice immunized with gK, but not with any other known HSV-1 glycoprotein, displayed significantly exacerbated CS, facial dermatitis, and blindness following ocular HSV-1 infection [3–6] and that these pathologies occur independent of the virus or mouse strain [5].