Current diagnostic methods epithelial ovarian cancer early detection mainly includes ultrasound and measurement of serum biomarkers such us carcinoembryonic antigen (CEA), cancer antigen-125 (CA-125), carbohydrate antigen 19–9 (CA19-9), and human epididymis protein 4 (HE4). This evidence concerns the gene WFDC2 and ovarian carcinoma.