WFDC2 and cancer: By combining the miRNAs with proteins (miRNA/protein score = miR-320b x 8.90 + miR-141-3p x 4.14 + CA-125 x 12.7 + HE4 x 11.7; cancer prediction threshold >127.2), a classification with 75.6% sensitivity and 100% specificity was obtained in the LOOCV (Fig 3A and Table 3).