The present study was aimed at investigating (1) the effects of β-agonist or cold exposure on IL-25 expression in the adipose tissue; (2) the effects of IL-25 on brite/beige adipocytes in WAT; (3) the role of macrophages in this process that IL-25 induces the beige fat; and (4) whether IL-25 restores the homeostasis against insulin resistance. This evidence concerns the gene IL25 and Insulin resistance.