Hence, evolved the rationale of treating cancer using secondary metabolites isolated from the plant extracts with the most effective mechanisms that enhance P53 protein expression, reducing the expression of proteins P27, P21, and NFκB and induction of apoptosis, inhibition of the PI3K/Akt pathway, and reduction of the level of acid phosphatase and lipid peroxidation of herbal plants that can inhibit cell cycle and proliferation [8, 9]. The gene discussed is TP53; the disease is cancer.