VDR and osteoporosis: This finding was supported and pooled in a large meta-analysis performed by Zhang et al. [22] who reported that there were significant correlations between VDR ApaI and postmenopausal osteoporosis susceptibility in the Caucasian populations and indicating that postmenopausal females having mutant allele of VDR ApaI might have less susceptibility to osteoporosis compared to those with wild genotype.