Among them, the presence of the VDR ApaI natural variant with obesity susceptibility was investigated in 3 studies [11, 29, 30] and the TaqI polymorphism by Yiannis et al. [31], Fan et al. [29], Al Hazmi et al. [11], and Bienertová-Vašků et al. [30]. This evidence concerns the gene VDR and obesity due to melanocortin 4 receptor deficiency.