EZH2 and diffuse large B-cell lymphoma: In cellular settings, 43c blocked the H3K27 di- and trimethylation in rhabdoid tumorcells with IC50 values of 0.390 and 0.090 μM, respectively,and this inhibition was selective over other histone target methylation.Regarding in vivo studies, He et al. tested 43c in a DLBCL Pfeiffer xenograft model by comparing its antitumorefficacy with the orthosteric EZH2 inhibitor GSK126, which due toPK issues, was administered subcutaneously at a dose of 300 mg/kgtwice per week.