EZH2 and cancer: In 2015, a differentwork described the discovery of the naturalcompound wedelolactone (2, Figure 4) being able to bind to EED with a micromolaraffinity (KD = 2.82 μM), to blockthe EZH2–EED interaction in vitro, to induce the degradationof both EZH2 and EED proteins at 50 μM in HepG2, THP1, and K562cells, and also to modulate the expression of detected PRC2 downstreamtargets and cancer-related genes.71