Medulloblastoma (MB) has been extensively analyzed in genomic, transcriptomic, and methylation studies classifying MB into molecular subgroups—Wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4—by clinically relevant and unique transcriptional, genomic, and epigenetic features.5, 6. This evidence concerns the gene SHH and medulloblastoma.