In the individuals with type 2 diabetes, a decrease in the measured insulin sensitivity was detected following MR blockade, during clamp stage 2, compared to before MR blockade (T2D: 153 ± 18 vs. 132 ± 24 ml h−1 prior vs. following intervention, p = 0.04) (Figure 2). The gene discussed is INS; the disease is type 2 diabetes mellitus.