Furthermore, in the phase 1b/2 M14-358 and phase 1b M14-387 studies, the BCL-2 inhibitor, venetoclax, in combination with azacitidine, decitabine, or LDAC, demonstrated encouraging CR rates and remission duration in AML patients of older age (≥60 yrs) or with comorbidities precluding the use of intensive induction chemotherapy. The gene discussed is BCL2; the disease is acute myeloid leukemia.