PLK1 and acute myeloid leukemia: The current randomized, double-blind, placebo-controlled, phase 3 trial was conducted to evaluate the efficacy and safety of volasertib, a highly potent and selective Plk inhibitor, combined with LDAC in previously untreated older patients with AML who were considered unsuitable for intensive chemotherapy, and aimed to confirm the encouraging results from the previous, randomized, open-label, phase 2 trial.10