Subgroup analysis of ORR showed differences in response rates by gender, age, weight, ECOG PS, 2010 ELN genetic risk group,13 type of AML, NPM1 mutation status, and geographical region of enrollment, with a trend toward better ORR with V+LDAC compared with P+LDAC in most subgroups (Table 3). This evidence concerns the gene NPM1 and acute myeloid leukemia.