In the intestine, NPC1 L1 and ABCG5/G8 are involved in TICE.[46,47] TICE is inducible by PCSK9 inhibitors or HMG-CoA reductase inhibitors (statins).[48,49] In both mice and humans, TICE can be stimulated by a NPC1 L1 inhibitor, ezetimibe, which induces ABCG5/ABCG8 to efflux cholesterol from the intestine to prevent atherosclerosis.[50,51]. Here, PCSK9 is linked to atherosclerosis.