Knockout of ANXA1 expression inhibited the proliferation, migration, and invasion of lung carcinoma cells (Fang et al., 2016), while the expression level of ITGA3 can be used as a diagnostic and prognostic marker for several malignant tumors (Koshizuka et al., 2017; Jiao et al., 2019; Ramovs et al., 2019). The gene discussed is ANXA1; the disease is cancer.