We further evaluated the correlations between age, the course of RA, indicators of disease activity [erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and disease activity score-28 considering the ESR (ESR-DAS28)], immunoglobulins (IgA, IgM, IgG), and typical antibodies of RA [RF, anti-CCP, anti-keratin antibody (AKA), and antiperinuclear factor (APF)] and these cell subsets. The gene discussed is CRP; the disease is rheumatoid arthritis.