The results reveal increases in the abundance of Tfh-like and PD-1+ Tfh-like cells and decreases in abundance of Treg, Tfr-like, and mTfr-like cells resulting in the imbalance of Tfh-like/Treg, Tfh-like/Tfr-like, and Tfh-like/mTfr-like cell ratios in RA. Here, TFRC is linked to rheumatoid arthritis.