To further determine the distributions of Tfh-like cell subsets, we evaluated the percentages of Tfh-like cell subsets in RA patients and healthy controls and found that Tfh17-like and Tfh1/17-like cells (CXCR3+CCR6+) were significantly elevated in RA patients compared with healthy controls. This evidence concerns the gene CXCR3 and rheumatoid arthritis.