However, the inhibition of p53 signaling, one of the key mediators controlling autophagy in tumor cells (Mrakovcic and Frohlich, 2018), was not able to suppress the H-RasG12V induced autophagy in keratinocytes, which suggests that p53 signaling may not be involved in autophagy formation induced by the overexpression of H-RasG12V. Here, TP53 is linked to neoplasm.