For example, NFAT1 (NFATc2) can cooperate with the Ras/Ras/MEK/ERK pathway to induce apoptosis in NIH3T3 fibroblasts, and the activation of NFAT1 can shift the oncogenic Ras pathway to act as a tumor suppressor (Robbs et al., 2013). This evidence concerns the gene MAP2K7 and neoplasm.