CLN3 and Childhood onset: Eukaryotic initiation factor 2 (eIF2) (Dever, 2002; Ye J. et al., 2010), initiation factor kinases, IfkA, IfkB, and IfkC (Fang et al., 2003; Rai et al., 2006), and Ceroid lipofuscinosis neuronal 3 (Cln3) and Cln5 that are associated with a childhood onset neurological disorder called Batten disease or neuronal ceroid lipofuscinosis (NCL) (Santavuori, 1988), are important for extracellular accumulation of AprA and CfaD (Bowman et al., 2011; Huber et al., 2014; Huber and Mathavarajah, 2018; Figure 3).