CXCL12 and neoplasm: The chemokine stromal derived factor-1/CXCL12 is involved in tumor growth, metastasis and promotion of tumor immunity (Chen et al., 1994; Jager et al., 1996), possibly because CXCL12 secreted by tumors decreases T-cell infiltration (Vianello et al., 2006; d’Onofrio, 2012).