VAPB and Motor neuron atrophy: YIF1A and possibly YIF1B interact with VAPB and its mutant VAPB-P56S, which has been linked to motor neuron degeneration in amyotrophic lateral scleroses type 8, indicating the interactions of the YIPF proteins with VAPB may have a significant role in the pathology of the mutant VAPB (Kuijpers et al., 2013).