Interestingly, QSOX2 silencing resulted in a significant reduction in the proportion of NSCLC cells in the S and G2/M phases of the cell cycle, and the expression of mitosis-associated proteins (CENPF and NUSAP1) was also significantly decreased in the QSOX2-inhibited group. The gene discussed is QSOX2; the disease is non-small cell lung carcinoma.