Metascape enrichment analysis revealed that “ribosome biogenesis,” “maturation of rRNA,” “TNF-alpha/NF-kappa B signaling pathway,” “negative regulation of ubiquitin ligase activity,” and “rRNA modification in the nucleus and cytosol” were enriched in biological processes and pathways that might be highly correlated with the malignant progression of HCC. The gene discussed is TNF; the disease is hepatocellular carcinoma.